- Title
- A simple matrix to predict treatment success and long-term survival among patients undergoing pancreatectomy
- Creator
- Fitzgerald, Timothy L.; Hunter, Lucas; Mosquera, Catalina; Jindal, Charulata; Biswas, Tithi; Zervos, Emmanuel; Efird, Jimmy T.
- Relation
- HPB Vol. 21, Issue 2, p. 204-211
- Publisher Link
- http://dx.doi.org/10.1016/j.hpb.2018.07.010
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2019
- Description
- Background: A more accurate measure of long-term survival among patients who have undergone a successful resection for pancreatic adenocarcinoma may be computed by accounting for time already survived during the initial treatment window. Methods: Patients diagnosed with pancreatic adenocarcinoma, from 2004 through 2013, were identified from the American College of Surgeons National Cancer Database (NCDB). A risk-stratification matrix was constructed including age, histopathologic factors and the use of adjuvant therapy, given successful treatment and survival at 3-month following diagnosis. Results: A total of 25,897 patients (50% male, 53% >65 years of age) presented with stage I-III pancreatic cancer. The majority of patients had tumors >2 cm size (82%), grade I/II (65%), lymphatic invasion (LI) (66%), and negative margins (76%). A survival advantage for adjuvant therapy was observed among all patients, independent of their risk-profile. For example, a patient =65 years of age, with early stage cancer (size =2 cm, grade I/II, -ve LI, -ve margins) who received adjuvant therapy had a 62% probability of being alive beyond three years (95%CI = 59%-66%). In contrast, the survival probability decreased to 53% (95%CI = 59%-66%) without adjuvant therapy. Conclusions: These results provide surgeons and patients with more accurate information regarding long-term survival, as well as the benefit of opting for adjuvant therapy after successful pancreatic surgery.
- Subject
- tumors; pancreatic adenocarcinoma; treatment; survival; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1458694
- Identifier
- uon:45478
- Identifier
- ISSN:1365-182X
- Language
- eng
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